publications
72. Spry, C.; Sewell, A. L.; Hering, Y.; Villa, M. V. J.; Weber, J.; Hobson, S. J.; Harnor, S. J.; Gul, S.; Marquez, R.; Saliba, K. J. “Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation” Eur. J. Med. Chem. 2017, in press. DOI 10.1016/j.ejmech.2017.08.050
71. Zambelloni, R.; Connolly, J. P.; Huerta-Uribe, A.; Burgess, K.; Marquez, R.; Roe, A. J. “Novel Compounds Targeting the Enterohemorrhagic Escherichia Coli Type Three Secretion System Reveal Insights into Mechanism of Secretion Inhibition” Molecular Microbiology 2017, in press. DOI 10.1111/mmi.13719
70. Cogswell, T. J.; Donald, C.; Marquez, R. “Synthesis of 3-Fluoropyrroles by Ring-Closing Metathesis” Synfacts 2016, 12, 351.
69. Matheson, M.; Wright, C.; Marquez, R. “Isoleucine-glycine-aspartic acid Peptidomimetics as Novel Wound Healing Agents in-vitro” Brit. J. Dermatol. 2016, 174, e57.
68. Huerta-Uribe, A.; Marjenberg, Z.; Yamaguchi, N.; Fitzgerald S.; Connolly, J. P.; Carpena, N.; Uvell, H.; Douce, G.; Elofsson, M.; Byron, O.; Marquez, R.; Gally, D.; Roe, A. J. “Identification and Characterization of Novel Compounds Blocking Shiga Toxin Expression in Escherichia coli O157:H7” Front. Microbiol. 2016, 7, 1930.
67. Cogswell, T. J.; Donald, C.; Marquez, R. “Flexible Synthesis of Polyfunctionalised 3-Fluoropyrroles” Org. Biomol. Chem. 2016, 14, 183.
66. Zambelloni, R.; Marquez, R.; Roe, A. J. “Development of Anti-virulence Compounds” Chem. Biol & Drug Design 2015, 85, 43.
65. Cogswell, T. J.; Donald, C.; Long, D.-L.; Marquez, R. “Short, Efficient Synthesis of Fluorinated d-Lactams” Org. Biomol. Chem. 2015, 13, 717.
64. Pasqua, A. E.; Ferrari, F. D.; Crawford, J. J.; Marquez, R. “Synthesis of (+)-crocacin D and simplified bioactive analogues” Bioorg. Med. Chem. 2015, 23, 1062.
63. Pasqua, A. E.; Ferrari, F. D.; Marquez, R. “Total synthesis of lansiumamides A and B and alatamide” Tetrahedron Lett. 2014, 55, 6042.
62. Hudson, B. D.; Due-Hansen, M. E.; Christiansen, E.; Hansen, A. M.; Mackenzie, A. E.; Murdoch, H.; Pandey, S. K.; Ward, R. J.; Marquez, R.; Tikhonova, I. G.; Ulven, T.; Milligan, G. “Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor” J. Biol. Chem. 2013, 288, 17296.
61. Sewell, A. L.; Hansen, A. M..; Petersen, R.; Long, D.-L.; Gadegaard, N.; Marquez, R. “New BODIPY Derivatives Amenable to “Click” and Peptide Chemistry” Tetrahedron 2013, 69, 8527.
60. Matheson, M.; Pasqua, A. E.; Sewell, A. L. "Practical and Efficient Synthesis of N-Formylbenzotriazole" Organic Syntheses 2013, 90, 358.
59. Ferrari, F.D.; Pasqua, A.E.; Nadin, A.; Ledgard, A; Marquez, R. “Convergent Approach to Complex Spirocyclic Pyrans: Practical Route to Oxo- Pinnaic Acid” Org. Biomol. Chem., 2013, 11, 3469.
58. Marquez, R.; Norman, D.; Schor, A.; Schor, S. “Targeting protein-protein interactions for the development of wound healing promoters” Diabetic Medicine 2012, 29, 64.
57. Pasqua, A.E.; Ferrari, F.D.; Hamman, C.; Liu, Y.; Crawford, J.J.; Marquez, R. “Step-Economic Synthesis of (+)-Crocacin C: A Concise Crotylboronation/[3,3]-Sigmatropic Rearrangement Approach” J. Org. Chem. 2012, 77, 6989.
56. Pasqua, A.E.; Ferrari, F.D.; Crawford, J.J.; Marquez, R. “Formal Synthesis of (+)-Crocacin C.” Tetrahedron Lett. 2012, 53, 2114.
55. Pasqua, A. E.; Crawford, J. J.; Marquez, R. “Protecting Group Free, Stereocontrolled Synthesis of β-Halo-enamides” J. Org. Chem. 2012, 77, 2149.
54. Egan, B. A.; Paradowski, M.; Thomas, L. E.; Marquez, R. “Synthesis of the C1-C16 Fragment of the Ajudazols” Tetrahedron, 2011, 67, 9700.
53. Pasqua, A. E.; Crawford, J. J.; Marquez, R. “Regioselective Synthesis of b-Iodo-enamides and -Yn-enamides.” Tetrahedron, 2011, 67, 7611.
52. Ferrari, F. D.; Ledgard, A. J.; Marquez, R. “Divergent Approach to the Pinnaic Acid and Polymaxenolide Cores” Tetrahedron 2011, 67, 4988.
51. Egan, B. A.; Paradowski, M.; Thomas, L. E.; Marquez, R. “Regiocontrolled Rearrangement of Isobenzofurans” Org. Lett. 2011, 13, 2086.
50. Pasqua, A. E.; Matheson, M.; Sewell, A. L.; Marquez, R. "Fast, Economic and Green Synthesis of N-Formylated Benzotriazoles" Org. Proc. Res. Dev. 2011, 15, 467.
49. Sewell, A. L.; Villa, M. V. J.; Matheson, M.; Whittingham, W. G.; Marquez, R. "Fast and Flexible Synthesis of Pantothenic Acid and CJ-15,801." Org. Lett. 2011, 13, 800.
48. Ramsay, A. K.; McCracken, S. R .C.; Soofi, M.; Fleming, J.; Yu, A. X.; Ahmad, I.; Morland, R.; Machesky, L.; Nixon, C.; Edwards, D. R.; Nuttall, R. K.; Seywright, M.; Marquez, R. Keller, E.; Leung, H. Y. “ERK5 signalling in prostate cancer promotes an invasive phenotype” Brit. Journal Cancer 2011, 104, 664.
47. Mathieson, J. E.; Crawford, J. J.; Schmidtmann, M.; Marquez, R. "Fast and efficient one step synthesis of dienamides." Org. Biomol. Chem. 2009, 7, 2170.
46. Meiries, S.; Parkin, A.; Marquez, R. “Synthesis of the trichloroacetamide derivative of enantio-iso-ADDA Methyl Ester” Tetrahedron 2009, 65, 2951.
45. Tillement, V.; Lajoie-Mazenc, I.; Casanova, A.; Froment, C.; Penary, M.; Tovar, D.; Marquez, R.; Monsarrat, B.; Favre, G.; Pradines, Anne. “Phosphorylation of RhoB by CK1 impedes actin stress fiber organization and epidermal growth factor receptor stabilization.” Exp. Cell Res. 2008, 314, 2811.
44. Meiries, S.; Marquez, R. "Convergent Synthesis of (2R,3R,8R,9R)-N-Boc-Adda" J. Org. Chem. 2008, 73, 5015.
43. Hobson, S. J.; Parkin, A.; Marquez, R. "Oxidative Rearrangements of Isobenzofurans: Studies towards the Synthesis of the Ajudazols" Org. Lett. 2008, 10, 2813.
42. Sgraja, T.; Alphey, M.; Ghilagaber, S.; Robertson, M.; Hemmings, J.; Marquez, R.; Lauw, S.; Rohdich, F.; Bacher, A.; Eisenreich, W.; Illarionova, V.; Hunter, W. “ Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; biochemical and structural characterization.” FEBS Journal, 2008, 275, 2779.
41. Abott, B. M.; Ferrari, F. D.; Barnes, J. C.; Harnor, S. J.; Marquez, R. “Photochemical synthesis of benz[h]isoquinolines.” Tetrahedron, 2008, 64, 5072.
40. Bulger P. G.; Bagal, S. K.; Marquez, R. “Recent Advances in Biomimetic Natural Product Synthesis.” Nat. Prod. Rep. 2008, 25, 254.
39. McCracken, S. R. C.; Ramsay, A.; Heer, R.; Mathers, M. E.; Jenkins, B. L.; Edwards, J. Robson, C. N.; Marquez, R.; Cohen, P.; Leung, H. Y. “Aberrant expression of extracellular signal-regulated kinase5 in human prostate cancer ” Oncogene, 2008, 27, 2978.
38. Villa, M. V. J.; Targett, S. M.; Barnes, J. C.; Whittingham, W. G.; Marquez, R. “An efficient approach to the stereocontrolled synthesis of enamides.” Org. Lett. 2007, 9, 1631.
37. Ghilagaber, S.; Hunter, W.N.; Marquez, R. “Enantioselective synthesis of C3 fluoro-MEP.” Org. Biomol. Chem. 2007, 5, 97.
36. Kiu, H.; Hilton, D. J.; Nicola, N. A.; Ernst, M.; Marquez, R.; Alexander, W. S.; Roberts, A.W.; Mcmanus, E. J. “ Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNF a” Growth Factors, 2007, 25, 319.
35. Tyler, R. K.; Shpiro, N.; Marquez, R.; Eyers, P.A. “VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.” Cell Cycle, 2007, 6, 2846.
34. Henry, N.; Robertson, M. N.; Marquez, R. “Fast and Efficient Synthesis of the Complete LL-Z1640-2 Framework.” Tetrahedron Lett. 2007, 48, 6088.
33. Logie, L.; Ruiz-Alcaraz, A.; Keane, M.; Woods, Y. L.; Bain, J.; Marquez, R.; Alessi, D. R.; Sutherland, C. “Characterisation of a Protein Kinase B Inhibitor in Vitro and In Insulin Treated Liver Cells.” Diabetes, 2007, 56, 2218.
32. Ghilagaber, S.; Hunter, W.N.; Marquez, R. “Efficient Coupling of Low Boiling Point Alkynes and 5-Iodo-Nuecleosides.” Tetrahedron Lett. 2007, 48, 483.
31. Hobson, S. J.; Marquez, R. “Synthesis Highly Functionalised Spirocyclic Pyrans.” Org. Biomol. Chem. 2006, 4, 3808.
30. Rousseau, S.; Dolado, I.; Beardmore, S.; Shpiro, N.; Marquez, R.; Nebreda, A. R.; Arthur, J. S. C.; Case, L. M.; Tessier-Lavigne, M.; Gaestel, M.; Cuenda, A.; Cohen, P. “CXCL12 and C5a trigger cell migration via a PAK1/2-p38a MAPK-MAPKAP-K2-HSP27 pathway.” Cellular Signalling, 2006, 18, 1897.
29. Shpiro, N.; Ellis, I.R.; Dines, T. J.; Schor, A. M.; Schor, S. L.; Norman, D. G.; Marquez, R. “Synthesis of an IGD Peptidomimetic with Motogenic Activity.” Molecular Biosystems 2005, 1, 318.
28. Buxade, M.; Parra, J. L.; Shpiro, N.; Marquez, R.; Rousseau, S.; Puga, I, Espel, E.; and Proud, C.G. “The MAP kinase-signal integrating kinase Mnk1 positively regulates the synthesis of tumour necrosis factor a via the 3’-untranslated region of its mRNA.” Immunity,2005, 23, 177.
27. Clokiel, S. J.; Cheung, K. Y.; Mackiel, S.; Marquez, R.; Pedenl, A. H.; Aitken, A. “BCR kinase Phosphorylates 14-3-3 Tau on Residue 233.” FEBS Journal 2005, 272, 3367.
26. Shpiro, N.; Marquez, R. “An improved synthesis of the potent MEK inhibitor PD184352” Synthetic Communications 2005, 35, 2265.
25. Baldwin, J. E.; Adlington, R. M.; Sham, V. W. W.; Marquez, R.; Bulger, P. G. “Biomimetic synthesis of (±)-aculeatin D.” Tetrahedron, 2005, 61, 2353.
24. Edward J. McManus, E. J.; Sakamoto, K.; Armit, L. J.; Ronaldson, L.; Shpiro, N.; Marquez, R.; Alessi, D. R. “Role that phosphorylation of Ser21 of GSK3 and Ser9 of GSK3 plays in insulin and Wnt-signalling defined by knockin analysis.” EMBO J. 2005, 24, 1571.
23. Kuma, Y.; Sabio, G.; Shpiro, N.; Márquez, R.; Cuenda, A. “BIRB0796 inhibits all p38MAPK isoforms in vitro and in vivo.” J. Biol. Chem. 2005, 280¸19472.
22. Bagal, S. K.; Adlington, R. M.; Baldwin, J. E.; Marquez, R. “Dimerization of Butenolide Structures. A Biomimetic Approach to the Dimeric Sesquiterpene Lactones (±)-Biatractylolide and (±)-Biepiasterolide” J. Org. Chem. 2004, 69, 9100.
21. Irlapati, N.R.; Adlington, R.A.; Conte, A.; Pritchard, G. J.; Marquez, R.; Baldwin, J. E. “Total synthesis of pyridovericin” Tetrahedron 2004, 60, 9307.
20. Murray, J. T.; Campbell, D. G.; Morrice, N.; Auld, G. C.; Shpiro, N.; Marquez, R.; Peggie, M.; Bain, J.; Grahemmer, F.; Lang, F.; Wulff, P.; Kuhl, D.; Cohen, P. “Exploitation of KESTREL to identify N-myc downstream-regulated gene family members as physiological substrates for SGK1 and GSK3” The Biochemical Journal, 2004, 384, 477.
19. Finlay, D.; Patel, S.; Dickson, L. M.; Shpiro, N.; Marquez, R.; Rhodes, C. J.; Sutherland, C. “Glycogen Synthase Kinase-3 Regulates IGFBP-1 Gene Transcription Through the Thymine-rich Insulin Response Element” BMC Molecular Biology 2004, 5, 15.
18. Paterson, I.; Davies, R. D. M.; Heimann, A. C.; Marquez, R.; Meyer, A. “Sterocontrolled Total Synthesis of (-)-Callipeltoside A”, Org. Lett. 2003, 5, 4477.
17. Moses, J. E.; Baldwin, J. E.; Adlington, R. M.; Cowley, A. R.; and Marquez, R. “Thermally Induced Cascade Peryclic Reaction Pathways from Tetraene Esters”, Tetrahedron Lett. 2003, 44, 6625.
16. Bagal, S. K.; Adlington, R.M.; Baldwin, J. E. and Marquez, R. “Biomimetic Synthesis of Biatractylolide and Biepiasterolide,” Org. Lett. 2003, 5, 3049.
15. Bagal, S. K.; Adlington, R.M.; Marquez, R.; and Baldwin, J. E. “Studies Towards the Biomimetic Synthesis of Bissesquiterpene Lactones,” Tetrahedron Lett. 2003, 44, 4993.
14. Moses, J. M.; Baldwin, J. E.; Marquez, R; Adlington, R. M; Claridge, T. C.; Odell, B. “Biomimetic Synthesis of the Crispatene Core,” Org. Lett. 2003, 5, 661.
13. Baldwin, J. E.; Adlington, R. M.; Wilkinson, P. J.; Marquez, R.; Adamo, M. F. A. “Studies Towards the Biomimetic Synthesis of Ginsenoyne” Heterocycles, 2003, 59, 81.
12. Moses, J. M.; Baldwin, J. E.; Marquez, R; Adlington, R. M; Cowley, A. R. “Studies on the Biomimetic Synthesis of SNF4435C and D,” Org. Lett. 2002, 4, 3731.
11. Baldwin, J. E.; Bulger, P. G; Marquez, R. “Fast and Efficient Synthesis of Novel Fumagillin Analogues,” Tetrahedron, 2002, 58, 5441.
10. Baldwin, J. E.; Adlington, R. M.; Conte, A.; Iriapati, N.; Marquez, R.; Pritchard, G. J. “Total Synthesis of Pyridovericin; Studies Towards the Biomimetic Synthesis of Pyridomacrolidin,” Org. Lett. 2002, 4, 2125.
9. Baldwin, J. E.; Adlington, R. M.; Roussi, F.; Bulger, P. G.; Marquez, R.; Mayweg, A. V. W. “Studies towards the Biomimetic Synthesis of the Nonadrides CP-225,917 and CP-263,114,” Tetrahedron 2001, 57, 7409.
8. Paterson, I.; Davies, R. B.; Marquez, R. “Total Synthesis of the Callipeltoside Aglycon,” Angew. Chem. Int. Ed. 2001, 40, 603.
7. Jung, M. E.; Marquez, R. “Efficient Synthesis of the C1-C11 Fragment of the Tedanolides. The Nonaldol Aldol Process in Synthesis,” Org. Lett. 2000, 2, 1669.
6. Beauchamp, P. S.; Marquez, R. “Studies Towards the Synthesis of Bicyclo[4.3.3]dodeca 1,5- diene,” Anales de Quimica, International Edition, (in press).
5. Jung, M.E.; Marquez, R. “Rearrangement of Epoxides in Non-Aldol Process: Allylic vs Tertiary and Secondary Carbocationic Centers,” Tetrahedron Lett., 1999, 40, 3129.
4. Jung, M.E.; Karama, U.; Marquez, R. “Conversion of Homoallylic Alcohols with Alkene Protection to the corresponding Methyl Ketones,” J. Org. Chem. 1999, 64, 663.
3. Jung, M. E.; Marquez, R.; Houk, K. N. “Theoretical Calculations to Predict Radical Cyclizations of Substituted 4-Pentenyl Halides to Produce Cyclobutanes,” Tetrahedron Lett., 1999, 40, 2661.
2. Jung, M. E.; Marquez, R. “Gem-Disubstituted Effects in Small Ring Formation: Novel Ketal Ring Size Effects,” Tetrahedron Lett. 1997, 38,
6521.
1. Beauchamp, P. S.; Marquez, R. “A General Approach to Calculate Proton Chemical Shifts for Methyl, Methylene and Methine Protons
Having One or More Substituents Within Three Carbons,” J. Chem. Ed. 1997, 74, 1483.